A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression

By Vasiliki Anest, J. Hanson, P. Cogswell, K. Steinbrecher, Brian D. Strahl, A. Baldwin. Nature, 2003

444 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/261597fa0a6811d94c239c683e9f9c70140f1468

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Citations in the corpus

Activation of IKKα target genes depends on recognition of specific κB binding sites by RelB:p52 dimers (2004, background): “…may contribute to selective IKKa-dependent gene activation and that IKKa may also be responsible in certain cell types for activation of the canonical NF-kB pathway (Cao et al, 2001) or for potentiating its ability to activate transcription (Anest et al, 2003; Israel, 2003; Yamamoto et al, 2003).”
NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review (2015, background): “IKKα has, for instance, been described to also have nuclear functions and serve as a regulator of canonical NF-κB-dependent gene expression through control of promoter-associated histone phosphorylation exposed to cytokines (Anest et al., 2003; Yamamoto et al., 2003).”
IκB Kinase α-Mediated Derepression of SMRT Potentiates Acetylation of RelA/p65 by p300 (2006, background): “IKK is chromatin associated, unlike other kinases capable of phosphorylating RelA/p65(S536) (4, 5, 12, 26, 34, 57, 67, 68).”
The NF-κB pathway (2005, background): “IKK is the specific catalytic subunit of the IKK complex that mediates this non-classical activation of NF- B. Interestingly, IKK has an additional nuclear role in that it catalyses the phosphorylation of histone H3 at NF- B-regulated promoters (Anest et al., 2003; Yamamoto et al., 2003).”
Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “H3S10 can be phosphorylated by a variety of kinases, such as mitogenand stress-activated protein kinase 1 and 2 (MSK1 and MSK2) (Soloaga et al., 2003), ribosomal S6 kinase 2 (RSK2) (Sassone-Corsi et al., 1999), I κB kinase-α (IKK-α) (Anest et al., 2003), and PIM1 kinase (Zippo et al., 2007).”
Mathematical model of NF- κB regulatory module (2004, background): “The basic role of IKKa in NF-kB signaling is different, it enters the nucleus and in conjunction with RelA is recruited to NF-kB responsive promoters (Yamamoto et al., 2003; Anest et al., 2003).”