TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.
By Felix L. Yeh, Yuanyuan Wang, I. Tom, Lino C. Gonzalez, Morgan Sheng. Neuron, 2016
796 citations recorded by the source corpus.
Subfields: Immunology, Neurology
View Paper: https://www.semanticscholar.org/paper/25c85d783177b0d7e8f3f39fbabafecd9785746d
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In Immunology
In Neurology
Citations in the corpus
- The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques (2019, background): “Interestingly, gene enrichment analysis indicates that ARMs, but not IRMs, are enriched for known AD risk genes such as Apoe, Trem2, Tyrobp (DAP12), Ctsb, Ctsd, H2-Eb1, and Pld3 (Cruchaga and Goate, 2015a, 2015b; Cruchaga et al., 2014; Fazzari et al., 2017; Heilmann et al., 2015; Hooli et al., 2015;”