Gold Nanocages as Photothermal Transducers for Cancer Treatment
By Jingyi Chen, C. Glaus, R. Laforest, Qiang Zhang, Miaoxian Yang, M. Gidding, M. Welch, Younan Xia. Small, 2010
661 citations recorded by the source corpus.
Gold nanocages represent a new class of nanomaterials with compact size and tunable optical properties for biomedical applications. They exhibit strong light absorption in the near-infrared region in which light can penetrate deeply into soft tissue. After PEGylation, the Au nanocages can be passively delivered to tumors in animals. Analysis of tissue distribution for the PEGylated Au nanocages showed that the tumor uptake was 5.7 %ID/g at 96 h post injection. The Au nanocages were found not only on the surface, but also in the core of the tumor. By exposing tumors to a near-infrared diode laser (0.7 W/cm2, CW, λ=808 nm) for 10 min, the photothermal effect of the Au nanocages could selectively destroy tumor tissue with minimum damage to the surrounding healthy tissue. Data from functional [18F]fluorodexoyglucose positron emission tomography revealed a decrease in tumor metabolic activity upon the photothermal treatment. Histological examination identified extensive damage to the nuclei of tumor cells and tumor interstitium.
Subfields: Biomedical Engineering, Electronic, Optical and Magnetic Materials
View Paper: https://www.semanticscholar.org/paper/25b2ef45ae85f767aa327284b1b4be3a0b3b2494
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Biomedical Engineering
In Electronic, Optical and Magnetic Materials
Citations in the corpus
- Gold nanostars: surfactant-free synthesis, 3D modelling, and two-photon photoluminescence imaging (2012, methodology): “Uniquely shaped nanoparticles have been used as contrast agents in optical bioimaging techniques [3, 13, 14], and as photothermal transducers for cancer treatment [7, 15–18].”
- Green Synthesis of Gold and Silver Nanoparticles Using Averrhoa bilimbi Fruit Extract (2013, background): “Among the various noble metal nanoparticles, gold and silver have several applications in sensors, detectors, and antibacterial agents [4–6].”