Epidemiology and Management of Hepatocellular Carcinoma

By L. Kulik, H. B. EL‐SERAG. Gastroenterology, 2018

1,125 citations recorded by the source corpus.

The major risk factors for hepatocellular carcinoma (HCC) in a contemporary clinical practice is becoming increasingly related to post sustained virological response hepatitis C, suppressed hepatitis B virus on treatment, alcoholic and non-alcoholic fatty liver disease. We review the emerging data on the risk and determinants of HCC in these conditions, and the implications to HCC surveillance. However, from a public health perspective, active hepatitis C and B continue to drive most of the global burden of HCC. In United States, the age adjusted incidence rates of HCC in Hispanics have surpassed that of Asians. Prognosis in HCC is complex due to the competing risk imposed by underlying cirrhosis and presence of malignancy. In addition to tumor burden, liver function and performance status, additional parameters including tumor biopsy, serum markers and sub classification of current staging systems, taking into account patterns of tumor progression, may improve patient selection for therapy. Advancements in the treatment of HCC has included identification of patients that are most likely to derive a clinically significant benefit from the available therapeutic options. Additionally, the combination strategies of locoregional therapies and/or systemic therapy are being investigated.

Subfields: Epidemiology, Hepatology

View Paper: https://www.semanticscholar.org/paper/25b258d708544b85271ae043466142242c60def1

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In Epidemiology

  1. Z. Younossi
  2. P. Golabi
  3. James M. Paik
  4. Alita Mishra

In Hepatology

  1. Z. Younossi
  2. Alita Mishra

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