A Single IGF1 Allele Is a Major Determinant of Small Size in Dogs

By N. Sutter, Carlos D. Bustamante, K. Chase, Melissa M. Gray, Keyan Zhao, Lan Zhu, B. Padhukasahasram, E. Karlins, Sean Davis, P. Jones and 11 more. Science, 2007

691 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Genetics

View Paper: https://www.semanticscholar.org/paper/25975b2d1c1b6cebeea8658f35b44117bfbe887d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

Citations in the corpus

Mechanisms and pathways of growth failure in primordial dwarfism. (2011, background): “For instance, a regulatory polymorphism of IGF-1 is the major determinant of body size in dogs (Sutter et al. 2007), determining the difference between Chihuahuas and Great Danes.”
The dog as a model for understanding human social behavior (2009, background): “, 2004) offer new opportunities for the utilization of dogs in the understanding of causal factors in human diseases and phenotypic malformations (Sutter et al., 2007).”
Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication (2010, neutral): “1; (2) geographical dog breed groups (Supplementary Table 1); and (3) wolves and dogs as separate groups.”
Dog Breeds and Their Behavior (2014, background): “…molecular geneticists have been able to identify alleles associated with the Insulin-like Growth Factor-1 (IGF1) gene that are present in all toy or miniature dog breeds, but absent from wolves and other wild canids, and very rare among large breed dogs (Sutter et al. 2007; Gray et al. 2010).”
Size Communication in domestic dog (Canis familiaris) growls. (2010, positive): “…2007a, b, 2008a, b; rhesus macaques: Fitch & Fritz 2006; Ghazanfar et al. 2007), size information may be particularly relevant in species where artificial breeding has created an exceptionally large range of size variation, such as the domestic dog (Coppinger & Coppinger 2001; Sutter et al. 2007).”
Endocrine Biomarkers of Growth and Applications to Aquaculture: A Minireview of Growth Hormone, Insulin‐Like Growth Factor (IGF)‐I, and IGF‐Binding Proteins as Potential Growth Indicators in Fish (2008, background): “A recent study in domesticated dogs Canis familiaris shows that IGF-I is crucial to regulating body size ( Sutter et al. 2007 ), and previous investigations using IGF-I knockout mice established that IGF-I is responsible for much of postnatal growth ( Lupu et al.”