Chromatin Higher Order Folding--Wrapping up Transcription

By P. J. Horn, C. Peterson. Science, 2002

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Fantastically plastic: fish larvae equipped for a new world (2013, background): “Changing the pattern of the wrap changes the expression of genes, either by modifying the shape of the histone proteins (i.e. cell differentiation) or by adding or removing methyl groups to the DNA and influencing the transcriptional activity (i.e. genetic imprinting; Horn & Petersen 2002).”
Shaping the nuclear action of NF-κB (2004, background): “Genes within dense HETEROCHROMATIN are maintained in a transcriptionally inactive state due to the inaccessibility of the involved promoters to RNA polymerase II and other cofactor”
Histone acetylation and deacetylation in yeast (2003, positive): “Instead, histone acetylation might prevent the folding of nucleosomal arrays into more complex structures that would otherwise be inhibitory for transcriptio”