Effects of testosterone replacement in hypogonadal men.

By P. Snyder, H. Peachey, J. Berlin, P. Hannoush, G. Haddad, A. Dlewati, Jill Santanna, Louise Loh, D. Lenrow, J. Holmes and 3 more. Journal of Clinical Endocrinology and Metabolism, 2000

661 citations recorded by the source corpus.

Subfields: Animal Science and Zoology, Cell Biology, Endocrinology, Diabetes and Metabolism

View Paper: https://www.semanticscholar.org/paper/2551eaf4c3bf688eb77506797f416a41fc68581f

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1. S. Bhasin
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Citations in the corpus

• The decline of androgen levels in elderly men and its clinical and therapeutic implications. (2005, background): “Whereas several studies that have indicated that androgen treatment improves sexual function of hypogonadal men have included some older patients (369, 420, 443, 445, 488), information from controlled trials specifically on sexual function in the elderly remains scarce.”
• Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. (2006, background): “Testosterone therapy of healthy, hypogonadal men also increases fat-free mass (29–38) and muscle strength (30) and decreases fat mass (29, 33, 35, 37).”
• Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. (2010, background): “Testosterone therapy of healthy, hypogonadal men also increases fat-free mass (47, 48, 54– 57) and muscle strength (47, 54) and decreases fat mass (47, 48, 57).”
• Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men. (2004, background): “In prior T replacement treatment of smaller numbers of hypogonadal men, no cancer of the prostate was reported (18, 23).”
• Advances in male contraception. (2008, background): “In healthy young men, exogenous androgens increase lean body mass and decrease fat mass in a dose-dependent manner (280), whereas androgen replacement in hypogonadal men results in similar improvements in body composition in addition to increasing bone mineral density (281, 282).”
• Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes. (2004, background): “Hypogonadism is associated with an increase in fat mass, decreased muscle mass, accelerated bone loss, and decreased libido, and treatment with T results in improvement in these parameters (42).”
• Testosterone dose-response relationships in healthy young men. (2001, positive): “Administration of replacement doses of testosterone to hypogonadal men (10, 12, 30, 45, 49) and of supraphysiological doses to eugonadal men (9, 22–23, 26) increases fat-free mass, muscle size, and strength.”