Readily Accessible Bicyclononynes for Bioorthogonal Labeling and Three-Dimensional Imaging of Living Cells
By J. Dommerholt, S. Schmidt, R. Temming, L. Hendriks, F. Rutjes, J. V. van Hest, D. Lefeber, Peter Friedl, F. V. van Delft. Angewandte Chemie, 2010
607 citations recorded by the source corpus.
symmetricaland display excellent reaction kinetics in strain-promotedcycloaddition reactions. Functionalized derivatives of BCNwere applied in the labeling of proteins and glycans, as well asin the three-dimensional visualization of living melanomacells.Based on the known reactivity enhancement of cyclo-propane fusion,
Subfields: Molecular Biology, Organic Chemistry, Radiology, Nuclear Medicine and Imaging
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In Molecular Biology
In Organic Chemistry
In Radiology, Nuclear Medicine and Imaging
Citations in the corpus
- Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation (2014, background): “The reactivity of the cyclooctyne can be modulated (Figure 5B) by appending electron withdrawing groups at the propargylic position (MOFO, DIFO) (Agard et al., 2006; Baskin et al., 2007), or by augmentation of strain energy through aryl ring (DIBO, DIBAC and BARAC) (Debets et al., 2010a; Jewett et a”