Locoregional cancer treatment with magnetic drug targeting.

By C. Alexiou, W. Arnold, R. Klein, F. Parak, P. Hulin, C. Bergemann, Wolf Erhardt, Stefan Wagenpfeil, A. Lübbe. Cancer Research, 2000

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Applications of magnetic nanoparticles in biomedicine (2003, unknown): “reported by several groups using animals models including swine [61, 62], rabbits [37] and rats [38, 63, 64].”
Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors. (2008, background): “For example, it has been shown that a nanoparticle-bound chemotherapeutic agent mitoxantrone could be completely released from the carrier within 60min [44].”
Magnetic Nanoparticles: Surface Effects and Properties Related to Biomedicine Applications (2013, unknown): “[145].”
Magnetic nanoparticles for drug delivery (2006, background): “…vivo, the therapeutic agent is then released from the magnetic carrier, either via enzymatic activity or through changes in physiological conditions such as pH, osmolality, or temperature, leading to increased uptake of the drug by the tumor cells at the target sites [e.g., Alexiou et al., 2000].”
Physical Principles of Nanoparticle Cellular Endocytosis. (2015, background): “With the rapid advance of nanotechnology, NPs of different types can now be synthesized with wellcontrolled size uniformity and shape (Table 1), many of which have manifested a great potential for a broad range of biomedical applications including in vitro/vivo diagnostics,(36) cell tracking,(37) mo”