Intraepithelial Carcinoma of the Fimbria and Pelvic Serous Carcinoma: Evidence for a Causal Relationship

By D. Kindelberger, Yonghee Lee, A. Miron, M. Hirsch, C. Feltmate, F. Medeiros, M. Callahan, Elizabeth I. O. Garner, R. W. Gordon, C. Birch and 3 more. American Journal of Surgical Pathology, 2007

1,129 citations recorded by the source corpus.

Subfields: Obstetrics and Gynecology, Pathology and Forensic Medicine, Reproductive Medicine

View Paper: https://www.semanticscholar.org/paper/2524f4e0138fd615e02bc0aee65d2e74c759c0f7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Obstetrics and Gynecology

1. E. Lengyel
2. J. Prat
3. Ie-Ming Shih
4. R. Kurman

In Reproductive Medicine

1. E. Lengyel
2. R. Kurman
3. J. Prat
4. Ie-Ming Shih

Citations in the corpus

• Ovarian cancer development and metastasis. (2010, background): “Crum and his group.(15,16) Complete sectioning of the fallopian tubes from 55 patients with pelvic serous carcinomas showed involvement of the inner lining of the fallopian tube in 41 (75%).”
• Molecular Pathogenesis and Extraovarian Origin of Epithelial Ovarian Cancer. Shifting the Paradigm (2011, neutral): “As previously noted, in studies of ovarian and primary peritoneal HGSC in which the fallopian tubes were completely sectioned using the SEE-FIM protocol (63), STICs were identified in 50-60% of cases (66,67).”
• Staging classification for cancer of the ovary, fallopian tube, and peritoneum (2014, background): “Although STIC is capable ofmetastasizing and, therefore, cannot be considered carcinoma in situ, compelling evidence for a tubal origin of BRCA-positive HGSC (approximately 60% of BRCA cases) has accumulated over the past decade [7,8].”
• The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and Expanded. (2016, background): “Subsequently, STICs were detected in 50% to 60% of women with sporadic HGSC when the fallopian tubes were completely processed with the sectioning and extensively examining the fimbria protocol.(71,72) It has been argued that STIC may be a metastasis rather than a precursor of HGSC, but accumulating”
• Ovarian carcinomas: five distinct diseases with different origins, genetic alterations, and clinicopathological features (2012, background): “Furthermore, the finding of identical TP53 mutations in both TIC and concomitant tumors classified as ovarian in origin [15] indicates a clonal relationship between them and suggests that the distal fallopian tube (fimbria) is an important site for the initiation of HGSC.”
• The Origin and Pathogenesis of Epithelial Ovarian Cancer- a Proposed Unifying Theory (2010, background): “It was subsequently proposed that a proportion of ovarian carcinomas might develop as a result of implantation of malignant cells from the tubal carcinoma to the ovary.34,35 The next important step linking what had been termed ‘‘tubal intraepithelial carcinoma’’ and, subsequently, ‘‘serous tubal int”
• OVARIAN LOW-GRADE AND HIGH-GRADE SEROUS CARCINOMA: Pathogenesis, Clinicopathologic and Molecular Biologic Features, and Diagnostic Problems (2009, background): “In 1 study, all fallopian tube tissue from consecutively accessioned pelvic serous carcinomas was submitted for histologic examination, and 48% of the tumors initially interpreted as ovarian in origin contained a TIC.52 In an analysis of ovarian high-grade serous carcinomas at The Johns Hopkins Hosp”