Translational control by 5’-untranslated regions of eukaryotic mRNAs

By A. Hinnebusch, I. Ivanov, Nahum Sonenberg. Science, 2016

992 citations recorded by the source corpus.

The eukaryotic 5′ untranslated region (UTR) is critical for ribosome recruitment to the messenger RNA (mRNA) and start codon choice and plays a major role in the control of translation efficiency and shaping the cellular proteome. The ribosomal initiation complex is assembled on the mRNA via a cap-dependent or cap-independent mechanism. We describe various mechanisms controlling ribosome scanning and initiation codon selection by 5′ upstream open reading frames, translation initiation factors, and primary and secondary structures of the 5′UTR, including particular sequence motifs. We also discuss translational control via phosphorylation of eukaryotic initiation factor 2, which is implicated in learning and memory, neurodegenerative diseases, and cancer.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/251abb01dbd9538cdd4a18f54977d1e553bd0ae7

Citations in the corpus

• Computed structures of core eukaryotic protein complexes (2021, neutral): “…the eukaryotic machinery for protein production has expanded in size and complexity ( 43 ), which facilitated the development of sophisticated mechanisms for the regulation of gene expression at the post-transcriptional level ( 44 ) and increased integration with the cellular environment ( 45 ).”