Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury
By L. Ortiz, M. Dutreil, C. Fattman, A. Pandey, German Torres, K. Go, D. Phinney. Proceedings of the National Academy of Sciences of the United States of America, 2007
1,044 citations recorded by the source corpus.
Subfields: Archeology
View Paper: https://www.semanticscholar.org/paper/24efed1c88268b365e1ce38ae3cb6e5b0117d6e2
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Citations in the corpus
- Comparative Analysis of Human Mesenchymal Stem Cells from Bone Marrow, Adipose Tissue, and Umbilical Cord Blood as Sources of Cell Therapy (2013, neutral): “Several studies have suggested MSCs of different origins inhibit LPS-induced inflammation in vivo and in vitro [35,36].”
- IL‐1, IL‐18, and IL‐33 families of cytokines (2008, background): “This experimental model of pulmonary fibrosis in humans was markedly ameliorated by treatment with IL-1Ra, the latter possibly produced in the lung by mesenchymal stem cells (48, 49).”
- Coronavirus disease 2019 (COVID-19): current status and future perspectives (2020, background): “injury and ARDS by suppressing infiltration of immune cells to pulmonary tissues and pro-inflammatory cytokine secretion [91-94].”
- The secretion profile of mesenchymal stem cells and potential applications in treating human diseases (2022, background): “Interleukin-1 receptor antagonist (IL-1Ra) produced by MSCs is reported to alter the inflammatory and fibrotic response during chronic lung injury.(155) IL-1Ra also can induce macrophage polarization from the M1 to M2 phenotype and accelerate wound healing.”
- Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent (2010, result): “These observations are consistent with studies that suggested IL10 could regulate the magnitude and effec tor function of Th17 responses (Fitzgerald et al., 2007; McGeachy et al., 2007; Chang et al., 2008).”
- Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung (2009, background): “(28) found that IL-1RA mediated the anti-inflammatory and anti-fibrotic effect of MSCs during bleomycin-induced lung injury in mice.”