Cytokine storm and sepsis disease pathogenesis

By B. Chousterman, F. Swirski, G. Weber. Seminars in Immunopathology, 2017

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Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes (2020, positive): “Cytokine storm is a key component of sepsis pathology early in the course of disease, and several clinical trials have evaluated the efficacy of blocking individual cytokines without success (Chousterman et al., 2017), although a subsequent meta-analysis of trials using anti-TNF-a therapies has indi”
The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China (2020, background): “In coronavirus pneumonia, such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), accompanied by rapid virus replication, a large number of inflammatory cell infiltration and CS led to acute lung injury, acute respiratory distress syndrome (ARDS) and death [1, 2”