Schema-Dependent Gene Activation and Memory Encoding in Neocortex

By Dorothy Tse, T. Takeuchi, M. Kakeyama, Y. Kajii, H. Okuno, C. Tohyama, H. Bito, Richard G. M. Morris. 2011

625 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology, Neuroscience

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Citations in the corpus

Continual Lifelong Learning with Neural Networks: A Review (2018, background): “Furthermore, evidence suggests that (i) the hippocampus supports additional forms of generalization through the recurrent interaction of episodic memories (Kumaran &McClelland, 2012) and (ii) if the new information is consistent with existing knowledge, then its integration into the neocortex is fas”
Distinct hippocampal-cortical memory representations for experiences associated with movement versus immobility (2017, positive): “We recorded activity in the CA1 region of the hippocampus and in PFC, both of which play critical roles in memory processes (Euston et al., 2012; Moscovitch et al., 2016; Spellman et al., 2015; Tse et al., 2011; Winocur and Moscovitch, 1990).”
Optogenetic Dissection of Entorhinal-Hippocampal Functional Connectivity (2013, neutral): “CNQX-APV cocktail (60), dissolved in sterile 0.”
The restless engram: consolidations never end. (2012, background): “The rapid schema–dependent learning was associated with upregulation of immediate-early genes in the medial prefrontal cortex (Tse et al. 2011), whereas pharmacological intervention targeted at that area prevented the new learning as well as the recall of consolidated information.”
Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning (2015, background): “Under the hypothesis of largely preconfigured neuronal sequences, learning is a synthesis of a matching process between preexisting neuronal events and their abstractions (“schemas”; Tse et al., 2011).”
The hippocampus and related neocortical structures in memory transformation. (2018, background): “Tse et al. [136,141] showed that building schemas implicates the mPFC and can facilitate associative learning that is mediated by the hippocampus.”
Memory consolidation. (2015, background): “The concept of rapid cortical tagging (Lesburgueres et al. 2011; Tse et al. 2011) suggests that, even if the hippocampus is normally engaged for a short period for “binding” disparate cortical networks during memory encoding and the early stages of consolidation, a memory trace of some kind is rapid”