Drug discovery in pharmaceutical industry: productivity challenges and trends.

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A Role for Fragment-Based Drug Design in Developing Novel Lead Compounds for Central Nervous System Targets (2015, methodology): “Template crystal structures are available for download from the Protein Data Bank 1 and the Cambridge Structure Database 2 .”
Machine learning applications in drug development (2019, background): “Conversely, the high failure rate of drug development pipelines, often at late stages of clinical testing, has always been a critical issue [4].”