A Host-Targeting Signal in Virulence Proteins Reveals a Secretome in Malarial Infection

By N. Hiller, S. Bhattacharjee, Christiaan van Ooij, K. Liolios, Travis Harrison, C. López-estraño, K. Haldar. Science, 2004

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A catalogue of the effector secretome of plant pathogenic oomycetes. (2006, background): “The RXLR motif is similar to a host-targeting signal that is required for translocation of proteins from malaria parasites (Plasmodium species) into the cytoplasm of host cells (36, 55), leading to the hypothesis that RXLR functions as a signal that mediates NBS-LRR: nucleotide binding site and leuc”
Host-microbe interactions: shaping the evolution of the plant immune response. (2006, neutral): “The RXLR mo- tifissimilartoahost-targetingsignalrequiredfortransloca-tion of malarial proteins into host cells (Hiller et al., 2004).”
The MEME Suite (2015, background): “(33) applied MEME and MAST iteratively.”
A Systematic Map of Genetic Variation in Plasmodium falciparum (2006, neutral): “A conserved pentameric sequence (Pexel motif) [41] and an 11-amino acid signal (host-targeting [HT] motif) [42], which are frequently found in parasite proteins that are targeted to the red blood cell, have been identified, and such proteins have been proposed as candidates for proteins interacting ”
Malaria: Biology and Disease. (2016, neutral): “of proteins out of the parasite and beyond the parasitophorous vacuole membrane to numerous locations within the parasite-infected erythrocyte (Hiller et al., 2004; Marti et al., 2004; Sargeant et al., 2006) (Figure 3).”