Impaired adult myelination in the prefrontal cortex of socially isolated mice

By Jia Liu, K. Dietz, J. M. DeLoyht, Xiomara Pedré, D. Kelkar, J. Kaur, V. Vialou, M. Lobo, D. Dietz, E. Nestler and 2 more. Nature Neuroscience, 2012

671 citations recorded by the source corpus.

Protracted social isolation of adult mice induced behavioral, transcriptional and ultrastructural changes in oligodendrocytes of the prefrontal cortex (PFC) and impaired adult myelination. Social re-integration was sufficient to normalize behavioral and transcriptional changes. Short periods of isolation affected chromatin and myelin, but did not induce behavioral changes. Thus, myelinating oligodendrocytes in the adult PFC respond to social interaction with chromatin changes, suggesting that myelination acts as a form of adult plasticity.

Subfields: Behavioral Neuroscience, Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/2450fd93219394689108f9e953a82914727627d0

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In Behavioral Neuroscience

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In Developmental Neuroscience

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Citations in the corpus

• Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain (2014, background): “Adult-born oligodendrocytes contribute to myelin remodeling throughout life (44), sensory deprivation via social isolation results in hypomyelination of the prefrontal cortex of mice (47, 48), and learning a new language (52) or complex motor tasks (45) have been shown to alter white-matter structur”
• RESILIENCE TRAINING THAT CAN CHANGE THE BRAIN (2018, background): “Even in adult rodents, prolonged isolation alters amygdala and MPFC integrity, and leads to anxietylike behavior (Lieberwirth, Liu, Jia, & Wang, 2012; Liu et al., 2012).”
• Using high-resolution quantitative mapping of R1 as an index of cortical myelination (2014, positive): “Cortical myelination is often used as a measure in studies of non-human animals, particularly in recent studies of learning and plasticity (Liu et al., 2012).”
• Oligodendrocytes: Myelination and Axonal Support. (2015, background): “…regulated by experience both during development and in adult life, thus, the extent of myelin sheath formation may also serve as a form of plasticity to adapt brain function to environmental stimuli (Fields 2008; Liu et al. 2012; Makinodan et al. 2012; Mangin et al. 2012; Young et al. 2013).”
• Discriminative and affective touch: sensing and feeling. (2014, result): “However, a similarly based social isolation study, but this time with adult mice, also reported impaired reduced adult myelination in PFC but interestingly found that in adults social reintegration normalized levels of myelination (Liu et al., 2012)—reinforcing the previous finding”