Is the incidence of rheumatoid arthritis rising? Results from Olmsted County, Minnesota, 1955-2007
By E. Myasoedova, Cynthia S. Crowson, Hilal Maradit Kremers, Terry M. Therneau, S. Gabriel. Arthritis & Rheumatism, 2010
789 citations recorded by the source corpus.
Objective To examine the trends in incidence and prevalence of rheumatoid arthritis (RA) from 1995 to 2007. Methods To augment our preexisting inception cohort of RA patients (1955-1994), we assembled a population-based incidence cohort of individuals aged ≥18 years who first fulfilled ACR 1987 criteria for RA between 1/1/1995 and 12/31/2007 and a cohort of patients with prevalent RA on 1/1/2005. Incidence and prevalence rates were estimated and were age- and sex-adjusted to the 2000 US whites. Trends in incidence rates were examined using Poisson regression methods. Results The 1995-2007 incidence cohort comprised 466 patients (mean age 55.6 years; 66% female; 69% rheumatoid factor positive). The overall age- and sex-adjusted annual RA incidence was 40.9/100,000 population. The age-adjusted incidence in women was 53.1/100,000 population,(in men: 27.7/100,000 population). During 1995-2007 there was a moderate increase in RA incidence in women (p=0.02), but not in men (p=0.74). The increase was similar among all age groups. The overall age- and sex-adjusted prevalence on 1/1/2005 was 0.72% (95% CI 0.66–0.77) up from 0.62% (95% CI 0.55–0.69) in 1995 (p<0.001). Applying the 1/1/2005 prevalence to the US 2005 population, an estimated 1.5 million US adults are affected by RA. This is up from the 1.3 million reported previously. Conclusion The incidence of RA appears to be rising in women during 1995-2007 period. The reasons for this recent increase in incidence are unknown, but environmental factors may play a role. A corresponding increase in prevalence of RA was also found.
Subfields: Nephrology, Rehabilitation, Rheumatology
View Paper: https://www.semanticscholar.org/paper/2441b415a15d98ac6cd2e0ce4aa5453ca7694e3e
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In Rheumatology
Citations in the corpus
- Diagnosis and Management of Rheumatoid Arthritis: A Review (2018, positive): “Thepeak incidence is in thesixth decade.(1) Previously, RA led to disability, inability to work, and increased mortality.”
- Obesity in autoimmune diseases: not a passive bystander. (2014, background): “RA has a higher prevalence in women than in men [43,44].”
- Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis (2020, background): “Risk factors for the development of RA were reported to include smoking, obesity, exposition to UV-light, sex hormones, drugs, changes in microbiome of the gut, mouth, and lung, periodontal disease (periodontitis), and infections [1,2,5,7,9,10].”