High-field MRI of brain cortical substructure based on signal phase

By Jeff H. Duyn, P. van Gelderen, Tie-Qiang Li, J. D. de Zwart, A. Koretsky, M. Fukunaga. Proceedings of the National Academy of Sciences of the United States of America, 2007

701 citations recorded by the source corpus.

Subfields: Atomic and Molecular Physics, and Optics, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/24008991f55a0c834e8860ba3abff6d1f69b8ccf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Atomic and Molecular Physics, and Optics

In Radiology, Nuclear Medicine and Imaging

Citations in the corpus

Myelin and iron concentration in the human brain: A quantitative study of MRI contrast (2014, background): “Recent studies by Duyn et al. (2007) show strong 115 phase differences in the cortex and white matter, which cannot easily be 116 explained by the small differences in iron content claimed in earlier 117 works.”
Quantitative susceptibility mapping (QSM) as a means to measure brain iron? A post mortem validation study (2012, positive): “…, at magnetic field strengths greater than 1.5 T the contrast-to-noise characteristics of GRE phase images are superior to magnitude images (Duyn et al., 2007) substantiating that QSM has the potential to be more sensitive with respect to magnetic tissue properties than conventional…”
Integrated Laplacian-based phase unwrapping and background phase removal for quantitative susceptibility mapping (2013, methodology): “Solving Equation [1] yields the unwrapped phase that is free of contributions from sources outside the FOV, whereas Equation [2] gives the susceptibility maps.”
Toward in vivo histology: A comparison of quantitative susceptibility mapping (QSM) with magnitude-, phase-, and R2⁎-imaging at ultra-high magnetic field strength (2013, positive): “The laminar substructure of the cortical GM differed depending on the anatomical region, i.e., a cortical layer with increased magnetic susceptibility, corresponding to the Stria of Gennari, was found in the GM of the primary visual cortex, V1, whereas a layer with reduced magnetic susceptibility wa”
Susceptibility Contrast in High Field MRI of Human Brain as a Function of Tissue Iron Content (2008, methodology): “With the advent of high field MRI, the potential of MRI for the study of brain iron has received increased attention (Abduljalil et al., il.com (B. Yao). c. 2003; Duyn et al., 2007).”
MR Vascular Fingerprinting: A New Approach to Compute Cerebral Blood Volume, Mean Vessel Radius, and Oxygenation Maps in the Human Brain (2013, background): “It has been shown that the phase evolution also contains valuable information about magnetic susceptibility (Duyn et al., 2007), orientation of myelin fibers (Liu, 2010), and oxygenation in large blood vessels (Haacke et al.”
MRI Estimates of Brain Iron Concentration in Normal Aging Using Quantitative Susceptibility Mapping (2011, methodology): “Because the background effects usually vary slowly across space, various methods have been proposed to filter them out based on this frequency characteristic, such as polynomial fitting (Duyn et al., 2007) and forward modeling to Neuroimage.”
Regional specificity of MRI contrast parameter changes in normal ageing revealed by voxel-based quantification (VBQ) (2011, methodology): “According to the common biophysical notion, the rate of longitudinal relaxation (R1) depends mainly on the mobility of water within its microenvironment and the effective transverse relaxation rate (R2*) is sensitive to the iron content of GM (Cherubini et al., 2009a; Duyn et al., 2007; Peran et al.”
Overview of quantitative susceptibility mapping (2017, background): “Finally, the resulting relationship between the background field-corrected magnetic field perturbation map ΔBint r → and the magnetic susceptibility distribution can then be written as: ΔBint r → ¼ B0 ∫ VOI χ r → ′ dz r→ r→′ d3 r → ′ [16] From tissue magnetic field perturbation to bulk magnetic susc”
Track-density imaging (TDI): Super-resolution white matter imaging using whole-brain track-density mapping (2010, neutral): “smaller voxels), and is part of the impetus for ultra-high field MRI at 7 T and beyond (Duyn et al., 2007).”
A method for estimating and removing streaking artifacts in quantitative susceptibility mapping (2014, background): “The signal phase of gradient echo MRI provides much higher gray– white matter contrast than the corresponding magnitude, and contains unique information regarding deoxyhemoglobin, iron, myelin, and tissue microstructure (Duyn et al., 2007; He and Yablonskiy, 2009; Rauscher et al., 2005).”
Quantitative Susceptibility Mapping of Human Brain Reflects Spatial Variation in Tissue Composition (2011, background): “Using gradient-echo MRI at 7T, Duyn et al. (2007) showed that phase contrast was associatedwithmajor fiber bundles withinwhitematter, while the contrast within gray matter exhibited characteristic layered structure.”