Local Radiation Therapy of B16 Melanoma Tumors Increases the Generation of Tumor Antigen-Specific Effector Cells That Traffic to the Tumor1

By A. Lugade, J. P. Moran, S. Gerber, R. Rose, J. Frelinger, E. Lord. Journal of Immunology, 2005

938 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/23eeabfb60c4ca41c3e832716826058f48a37eb4

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Citations in the corpus

Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies. (2016, background): “Ionizing radiation is known to lead to immunogenic death of cancer cells in the tumor microenvironment [98], which can in turn result in proimmunogenic effects such as increased antigen presentation by tumor cells, increased chemokine release, and recruitment of effector T cells to the tumor microen”
Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies. (2015, background): “Ionizing radiation is known to lead to immunogenic death of cancer cells in the tumor microenvironment [98], which can in turn result in proimmunogenic effects such as increased antigen presentation by tumor cells, increased chemokine release, and recruitment of effector T cells to the tumor microen”
Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy (2006, background): “This is probably not due only to up-regulation of MHC class I expression because mTOR activation will have more general eff ects on protein expression including up-regulation of Fas, ICAM-1 (38), and interferon expression (33, 34).”
Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells (2008, result): “results are consistent with previous observations that radiation can enhance T cell infiltration of tumors (22, 23) and suggest that CD8 T cells of the Tc1 type are responsive to changes produced by tumor irradiation.”
Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts (2010, background): “…hosts, RT may also contribute by sensitizing the tumor stroma (Zhang et al., 2007) and by increasing the expression of adhesion molecules on the tumor vasculature, which would render the tumor susceptible to T cell infiltration (Ganss et al., 2002; Lugade et al., 2005; Quezada et al., 2008).”
Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade. (2014, background): “of radiotherapy, emergingevidence suggests that the generation of antitumor immune responses may play an important role in the effectiveness of this treatment (4, 5).”