The assessment of fracture risk.

By A. Unnanuntana, Brian P. Gladnick, E. Donnelly, J. Lane. Journal of Bone and Joint Surgery. American volume, 2010

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Proposed guidelines for the diagnosis and management of methylmalonic and propionic acidemia (2014, background): “Tools assessing fracture risk (such as FRAX) [281,282] are not designed or validated for this patient group, and therefore are not suitable for guiding treatment decisions.”
American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline (2016, positive): “These risk factors are cumulative with other known risk factors, including age, prior fracture history, and family history of fracture.(119,120) Lifestyle-related factors, including smoking, excess alcohol, inadequate exercise, low calcium, and vitamin D deficiency, are common in this population and”
European guidance for the diagnosis and management of osteoporosis in postmenopausal women (2008, background): “7 million fractures in men and women in Europe at a direct cost (2006) of €36 billion [12].”
Case finding for the management of osteoporosis with FRAX®—assessment and intervention thresholds for the UK (2008, methodology): “The independent contribution of each of these risk factors to fracture risk, determined from a series of meta-analyses of nine population-based cohorts (190,000 patient years) from Europe, North America, Japan and Australia [9] has been validated in a further 11 independent cohorts (1.2 million pers”