Issues with threshold masking in voxel-based morphometry of atrophied brains

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Anatomically-constrained tractography: Improved diffusion MRI streamlines tractography through effective use of anatomical information (2012, methodology): “A brainmaskwas then determined for the DW images, by combining individual masks derived from the mean-b=0 and mean-DWI images, with the threshold for each mean image determined using a parameterfree approach (Ridgway et al., 2009).”
Head size, age and gender adjustment in MRI studies: a necessary nuisance? (2010, background): “1 and therefore perhaps be unduly influenced by a single poorly registered scan (Ridgway et al., 2009).”
Connectivity-based fixel enhancement: Whole-brain statistical analysis of diffusion MRI measures in the presence of crossing fibres (2015, background): “It is worth emphasising that the issue of choosing the optimal analysis mask threshold is not unique to the proposed ﬁ xel-based analysis method (Ridgway et al., 2009).”