Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID‐19
By Yong Gao, Tuantuan Li, Mingfeng Han, Xiuyong Li, Dong Wu, Yuanhong Xu, Yulin Zhu, Yan Liu, Xiaowu Wang, Linding Wang. Journal of Medical Virology, 2020
933 citations recorded by the source corpus.
The role of clinical laboratory data in the differential diagnosis of the severe forms of COVID‐19 has not been definitely established. The aim of this study was to look for the warning index in severe COVID‐19 patients. We investigated 43 adult patients with COVID‐19. The patients were classified into mild group (28 patients) and severe group (15 patients). A comparison of the hematological parameters between the mild and severe groups showed significant differences in interleukin‐6 (IL‐6), d‐dimer (d‐D), glucose, thrombin time, fibrinogen, and C‐reactive protein (P < .05). The optimal threshold and area under the receiver operator characteristic curve (ROC) of IL‐6 were 24.3 and 0.795 µg/L, respectively, while those of d‐D were 0.28 and 0.750 µg/L, respectively. The area under the ROC curve of IL‐6 combined with d‐D was 0.840. The specificity of predicting the severity of COVID‐19 during IL‐6 and d‐D tandem testing was up to 93.3%, while the sensitivity of IL‐6 and d‐D by parallel test in the severe COVID‐19 was 96.4%. IL‐6 and d‐D were closely related to the occurrence of severe COVID‐19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID‐19 patients, which has important clinical value.
Subfields: Epidemiology, Infectious Diseases
View Paper: https://www.semanticscholar.org/paper/2384d08b6066ffd2b3726c0bcd2cb1a24cf2727e
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In Epidemiology
Citations in the corpus
- COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up (2020, background): “Disease severity is variably associated with prolongation of the prothrombin tim e (PT) and international normalized ratio (INR) (1,20,26), and thrombin time (TT) (27), and v ariably by a trend toward shortened activated partial thromboplastin time (aPTT) (1,16,19,28).”
- COVID-19 pathophysiology: A review (2020, positive): “As in line with the high prevalence of multiorgan failure, high d-dimer levels, fibrinogen and prolonged thrombin time were seen in severe diseases [17].”
- The impact of COPD and smoking history on the severity of COVID‐19: A systemic review and meta‐analysis (2020, background): “It is, thus, not surprising to find a worse prognosis of COVID‐19 in patients with COPD.”
- Predictors of COVID-19 severity: A literature review (2020, background): “If this is proven, then targeting ACE2 expression in the nasal epithelium may be a potential therapeutic approach to reduce transmission of COVID-19.”
- The COVID-19 Cytokine Storm; What We Know So Far (2020, background): “assessed 43 patients in China and reported that levels of IL-6 were significantly higher in severe cases (n = 15) than in mild cases (n = 28) (22).”