Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling.

By M. Goumans, Gudrun Valdimarsdottir, S. Itoh, F. Lebrin, Jonas Larsson, C. Mummery, S. Karlsson, P. ten Dijke. Molecules and Cells, 2003

749 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/2373accc7eb0ddec8e719d1b7d4dc483c182c1f9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. R. Derynck
2. P. ten Dijke
3. Xin-Hua Feng
4. K. Miyazono
5. H. Ikushima
6. Yvan Saeys
7. Nikolaos G. Frangogiannis
8. J. Massagué

In Oncology

1. R. Derynck
2. H. Ikushima
3. K. Miyazono
4. P. ten Dijke
5. R. Weinberg
6. D. Hanahan

In Pathology and Forensic Medicine

1. P. ten Dijke
2. R. Derynck

Citations in the corpus

• TGFβ signalling: a complex web in cancer progression (2010, background): “Although activin receptor-like kinase 5 ( ALK5 ; also known as TGFBR1) transduces TGFβ signalling in most cell types, ALK1 and other type 1 receptors are also activated in response to TGFβ stimulation in certain cell”
• Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches (2022, background): “As TGF-bwas also found to participate in an ALK1-TGF-b receptor containing signaling complex (Goumans et al., 2003), we thus examined whether TGF-b signaling is important for KCs.”
• Tumour microenvironment: TGFβ: the molecular Jekyll and Hyde of cancer (2006, neutral): “TGFβ ligands preferentially bind to TβRII homodimers, and the ligand-bound receptor complex has a high affinity for binding to and transactivating the TβRI receptors, resulting in an activated heteromeric signalling comple”
• Endoglin promotes endothelial cell proliferation and TGF‐β/ALK1 signal transduction (2004, background): “Finally, we have recently shown that ALK5 activity is necessary for ALK1 signalling (Goumans et al, 2003).”
• Extracellular control of TGFβ signalling in vascular development and disease (2007, background): “In ECs, TGFβ can transduce signals via ALK1 in addition to ALK5, and is thought to contribute to the bifunctional effects of TGFβ on angiogenesi”
• SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS (2005, background): “The opposing activities of TGF-β signaling through TβRI and ALK1, in complex with TβRII, define the balance in endothelial cell migration and proliferation (Goumans et al. 2003).”
• TGF-β signalling pathway and breast cancer susceptibility (2011, background): “No tSNPs in the genes of the endothelial-specific ALK1/SMADs 1&5 pathway, which promotes angiogenesis (14, 15), have been identified as associated with breast cancer risk.”