In the Light of Evolution III: Two Centuries of Darwin Sackler Colloquium: In the light of directed evolution: Pathways of adaptive protein evolution
By J. D. Bloom, Frances H. Arnold. 2009
262 citations recorded by the source corpus.
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
- Douglas M. Fowler
- Stanley Fields
- Tanja Kortemme
- Carlos L. Araya
- Colin A. Smith
- Dan S. Tawfik
- Birgit Mitter
- Wentao Chen
Citations in the corpus
- Predicting the Tolerated Sequences for Proteins and Protein Interfaces Using RosettaBackrub Flexible Backbone Design (2011, background): “mutations [4], or characterizing potential evolutionary pathways [5].”
- Stability effects of mutations and protein evolvability. (2009, background): “Other questions remain open, such as what role did compensatory/stabilizing mutation and chaperone buffering play in natural evolution? Do certain traits trade off, such as high stability and evolvability, or neutrality (minimal effects of mutations) and evolvability (the ability of few mutations to”
- A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function (2012, background): “The interplay between activating mutations and stabilizing mutations has implications for both protein evolution and protein engineering (9, 10, 16).”
- Microbiome definition re-visited: old concepts and new challenges (2020, background): “This becomes obvious when considering that the replacement of one single amino acid residue by another may lead to a radical functional change, resulting in an incorrect functional assignment to a given gene sequence [113].”
- Inferring fitness landscapes by regression produces biased estimates of epistasis (2014, unknown): “Proc Natl Acad Sci USA 92(21):9657–9661.”
- Engineering of TEV protease variants by yeast ER sequestration screening (YESS) of combinatorial libraries (2013, background): “Therefore, the YESS system provides a means to address and overcome a major issue in protease engineering, and in directed evolution in general, which is that overwhelmingly, mutations that increase the catalytic activity toward a desired substrate also result in relaxed specificity or higher cataly”