DNA translocation through graphene nanopores.
By G. Schneider, S. W. Kowalczyk, V. Calado, G. Pandraud, H. Zandbergen, Lieven M. K. Vandersypen, Cees Dekker. Nano letters (Print), 2010
777 citations recorded by the source corpus.
Nanopores--nanosized holes that can transport ions and molecules--are very promising devices for genomic screening, in particular DNA sequencing. Solid-state nanopores currently suffer from the drawback, however, that the channel constituting the pore is long, approximately 100 times the distance between two bases in a DNA molecule (0.5 nm for single-stranded DNA). This paper provides proof of concept that it is possible to realize and use ultrathin nanopores fabricated in graphene monolayers for single-molecule DNA translocation. The pores are obtained by placing a graphene flake over a microsize hole in a silicon nitride membrane and drilling a nanosize hole in the graphene using an electron beam. As individual DNA molecules translocate through the pore, characteristic temporary conductance changes are observed in the ionic current through the nanopore, setting the stage for future single-molecule genomic screening devices.
Subfields: Biomedical Engineering, Materials Chemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/231d6c5b350270be39921b7148e4237803818d00
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In Biomedical Engineering
- A. Castellanos-Gómez
- Herre S. J. van der Zant
- G. Steele
- M. Buscema
- N. M. R. Peres
- E. Prada
- M. Wanunu
- Phaedon Avouris
In Materials Chemistry
- A. Castellanos-Gómez
- G. Steele
- Herre S. J. van der Zant
- M. Buscema
- N. M. R. Peres
- H. Zandbergen
- K. Novoselov
- Yong‐Wei Zhang
In Molecular Biology
Citations in the corpus
- Isolation and characterization of few-layer black phosphorus (2014, background): “Furthermore, the nonspecific hydrophobic interactions between DNA molecules and pristine graphene also limits its use as nanopore material in DNA sequencing because of the rapid clogging of the nanopores [42, 43].”
- Colloquium: The transport properties of graphene: An introduction (2010, background): “Also in biophysics, graphene is finding new applications (Lu et al., 2010; Schneider et al., 2010; Wu et al., 2010).”