Biodegradable polymeric nanoparticles as drug delivery devices.

By K. Soppimath, T. Aminabhavi, A. R. Kulkarni, W. Rudzinski. Journal of Controlled Release, 2001

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Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery. (2011, background): “In the past two decades, tremendous efforts have been directed to the development of targeted drug delivery systems because they promise to resolve several key therapeutical issues associated with current clinical practice including low treatment efficacy and significant side effects [1,2].”
Engineered nanoparticles as precise drug delivery systems (2006, methodology): “Earlier reviews [Soppimath et al., 2001; Panyam and Labhasetwar, 2003] were dedicated to biodegradable nanoparticles preparation methods, drug loading, and their potential use in drug delivery systems.”
PLGA-based nanoparticles: an overview of biomedical applications. (2012, background): “Depending on the polymer and the surface modification, the zeta potential values may be positive, neutral or negative [16].”