New consensus nomenclature for mammalian keratins
By J. Schweizer, P. Bowden, P. Coulombe, L. Langbein, E. Lane, T. Magin, L. Maltais, M. Omary, D. Parry, M. Rogers and 1 more. Journal of Cell Biology, 2006
744 citations recorded by the source corpus.
Keratins are intermediate filament–forming proteins that provide mechanical support and fulfill a variety of additional functions in epithelial cells. In 1982, a nomenclature was devised to name the keratin proteins that were known at that point. The systematic sequencing of the human genome in recent years uncovered the existence of several novel keratin genes and their encoded proteins. Their naming could not be adequately handled in the context of the original system. We propose a new consensus nomenclature for keratin genes and proteins that relies upon and extends the 1982 system and adheres to the guidelines issued by the Human and Mouse Genome Nomenclature Committees. This revised nomenclature accommodates functional genes and pseudogenes, and although designed specifically for the full complement of human keratins, it offers the flexibility needed to incorporate additional keratins from other mammalian species.
Subfields: Cell Biology, Epidemiology, Genetics
View Paper: https://www.semanticscholar.org/paper/2294618597982c56b29484b1887b5e333aaf2b36
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
Citations in the corpus
- Keratin: Structure, mechanical properties, occurrence in biological organisms, and efforts at bioinspiration (2016, neutral): “These keratinous materials, having a high content of cysteine that distinguishes them from other proteins, are typically durable, tough and unreactive to the natural environment; they are assumed to provide mechanical support and diverse protective functions in the adaptation of vertebrates to the e”
- The human keratins: biology and pathology (2008, background): “Very recently, the “Keratin Nomenclature Committee” established the novel consensus nomenclature for mammalian keratin genes and proteins (Schweizer et al. 2006),”
- Structure and functions of keratin proteins in simple, stratified, keratinized and cornified epithelia (2009, background): “KRT10 is the gene of the human keratin K10 (Hesse et al. 2001, 2004; Schweizer et al. 2006).”
- A Review of Keratin-Based Biomaterials for Biomedical Applications (2010, background): “holds the cortical superstructure together and are also termed keratin associated proteins or KAPs [4].”