Mechanotransduction and extracellular matrix homeostasis
By Jay D. Humphrey, E. Dufresne, M. Schwartz. Nature reviews. Molecular cell biology, 2014
1,950 citations recorded by the source corpus.
Soft connective tissues at steady state are dynamic; resident cells continually read environmental cues and respond to them to promote homeostasis, including maintenance of the mechanical properties of the extracellular matrix (ECM) that are fundamental to cellular and tissue health. The mechanosensing process involves assessment of the mechanics of the ECM by the cells through integrins and the actomyosin cytoskeleton, and is followed by a mechanoregulation process, which includes the deposition, rearrangement or removal of the ECM to maintain overall form and function. Progress towards understanding the molecular, cellular and tissue-level effects that promote mechanical homeostasis has helped to identify key questions for future research.
Subfields: Cell Biology, Genetics, Immunology and Allergy
View Paper: https://www.semanticscholar.org/paper/227293d02bd56d654571e233905da6cd30eaae93
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cell Biology
- Alexandra Naba
- Steven A. Carr
- Karl R. Clauser
- R. Hynes
- X. Trepat
- Peter Friedl
- M. Humphries
- Stephanie Alexander
In Immunology and Allergy
- Alexandra Naba
- Steven A. Carr
- Karl R. Clauser
- R. Hynes
- Peter Friedl
- M. Humphries
- Stephanie Alexander
- Jonathan C. Kagan
Citations in the corpus
- Statics and Dynamics of Soft Wetting (2020, background): “Contact line forces provide a unique mechanical probe of biological matter, while drops on gels offer a model system to study principles of mechanobiology (Schwarz & Safran 2013, Charras & Sahai 2014, Humphrey et al. 2014).”
- Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores. (2017, positive): “Thus, targeting the mechanical connection between the nucleus and the cytoskeleton (i.e., the LINC complex) emerges as a potential approach to prevent the adverse effects of tissue stiffening in different diseases (Humphrey et al., 2014; Kumar and Weaver, 2009).”
- The Extracellular Matrix: Tools and Insights for the “Omics” Era (2015, background): “The ECM is the three-dimensional architectural scaffold that defines tissue boundaries and biomechanical properties [1] and cell polarity.”