Metabolomics: Methodologies and applications in the environmental sciences

By C. Lin, Mark R. Viant, R. Tjeerdema. 2006

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Environmental metabolomics: an emerging approach to study organism responses to environmental stressors (2013, methodology): “Direct injection MS enables the injection of a crude extract directly into an electrospray mass spectrometer, resulting in one spectrum per sample, but this method is not particularly quantitative (Lin et al. 2006).”
An environmental 1H NMR metabolomic study of the exposure of the marine mussel Mytilus edulis to atrazine, lindane, hypoxia and starvation (2009, methodology): “Recently a range of chromatographic and spectroscopic methods has been used in metabolomic studies to identify changes in the composition of the small molecular weight metabolites in either biofluids or tissues extracts ( Lin et al. 2006 ).”
1H NMR and GC/MS metabolomics of earthworm responses to sub-lethal DDT and endosulfan exposure (2009, background): “Metabolomics offers a promising and innovative way to characterize the biochemical response of an organism to contaminant exposure and identify potential biomarkers of exposure ( Lin et al. 2006; Robertson 2005).”