Liver regeneration.

By N. Fausto, J. Campbell, K. Riehle. Journal of Hepatology, 2012

2,303 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/21f6df3ee2f5cbc679bea5c355316a5f45a68bd7

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Citations in the corpus

Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration (2010, methodology): “This is plausible because HGF does not only induce proliferation but also serves as a chemoattractant for hepatocytes (1) and thus may provide a mechanism that contributes to the proposed HSA.”
The Hippo Signaling Pathway in Development and Cancer (2010, background): “For example, when two-thirds of a mouse liver is surgically removed, the remaining one-third regenerates its original mass within 7–10 days and then ceases growth (reviewed in Michalopoulos and DeFrances, 1997).”
Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer (2013, neutral): “This could be particularly relevant in patients with hepatic metastasis as the liver is a known reservoir for HGF (48).”
Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. (2010, background): “These two attributes of the model are the major reason for its usefulness, enhanced popularity, and acceptance through the years by many investigators.(1,2) Although the model of PHx is a relatively “clean” one, it should be emphasized that in human disease settings, many processes involving innate ”
A Human Liver Cell Atlas reveals Heterogeneity and Epithelial Progenitors (2019, positive): “Zonation profiles of GLUL (central), APOE (midzonal), CYP1A2 and CYP2E1 (central/midzonal), ALB and PCK1 (periportal), and immunostaining (bottom left) of GLUL, APOE, CYP1A2, and CYP2E1 from the Human Protein Atlas31.”
The Hippo signaling pathway in stem cell biology and cancer (2014, neutral): “Liver regeneration has been known for many years, although the underlying mechanisms and how the liver senses when it has reached its original size are still poorly understood [90].”
Hepatic Inflammation and Fibrosis: Functional Links and Key Pathways (2015, background): “Wound-healing responses to acute injury are beneficial in several ways: (1) Fibrosis provides mechanical stability; (2) inflammatory cells contribute to the removal of cellular debris; and (3) inflammatory signals also exert important functions in the promotion of liver regeneration.(12) Together, t”
BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “Although stemlike cells are thought to be present in the periportal regions of the liver (72, 118), the bulk of “liver regeneration” takes place by proliferation of the existing mature cellular populations composing the intact organ (149).”
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013, neutral): “…cells and their role in hepatotoxicity The major cell type of the liver is the hepatocyte, a parenchymal cell, which makes up to 80 % of the entire liver mass and performs the majority of the liver functions (Kmiec 2001; Lippincott 1993; Saunders 1996; Michalopoulos 2007; Tanaka et al. 2011).”
Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration (2010, neutral): “2) 8 , 13 , 19 , in the PH model, resection of 70% of the liver mass without perturbing the integrity of the residual liver vasculature 11 activates hepatocyte regeneration 15 - 17 .”