β-Catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression

By Shiaw-Yih Lin, W. Xia, Jo C. Wang, K. Kwong, B. Spohn, Y. Wen, R. Pestell, M. Hung. 2000

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Wnt signaling in cancer. (2012, background): “hyperactive signaling is apparent, particularly in cancers classified as basal-like or triple negative type (Lin et al. 2000; Chung et al. 2004; Howe and Brown 2004; Khramtsov et al. 2010; Geyer et al. 2011).”
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation (2008, background): “, where β-catenin stimulates c-Myc and cyclin D1 transcription that, in turn, facilitate cell proliferatio”
Minireview: Cyclin D1: normal and abnormal functions. (2004, background): “Many oncogenic signals induce cyclin D1 expression and do so through distinct DNA sequences in the cyclin D1 promoter including Ras (21); Src (22); ErbB2 (23); -catenin (24, 25); oncogenic signal transducer and activator of transcriptions (STATs) (26–28); and simian virus 40 small t antigen, a parti”
Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex (2004, background): “…-catenin allele (Chan et al., 2002); growth defects in clones lacking constitutive CRT are seen only at low cell densities,(Chesire et al., 2002; Lin et al., 2000; Mulholland et al., 2002), we compared the activity of six compounds toward HCT116 which implies a limited role for -catenin in cell…”