Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial.

By B. O'Sullivan, A. Davis, R. Turcotte, R. Bell, C. Catton, P. Chabot, J. Wunder, Rita Kandel, K. Goddard, A. Sadura and 2 more. The Lancet, 2002

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Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma. (2005, methodology): “All rights rese [3,4,15,18,20] and late radiation effects such as subcutaneous tissue fibrosis, edema, joint stiffness, and bone changes including osteoradionecrosis and fracture [2,5,15,17,21,25].”
Soft tissue and visceral sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. (2012, background): “If it is anticipated that wound complications will be a manageable problem, neoadjuvant radiotherapy, possibly in combination with chemotherapy [10] to a total dose of 50 Gy in 1.”
Soft tissue and visceral sarcomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up. (2018, background): “8–2 Gy fractions, followed by surgery may be considered [15].”
Soft Tissue Sarcomas (2001, methodology): “The only randomized comparison of preoperative and postoperative radiation therapy for soft tissue sarcoma conducted to date was performed by the National Cancer Institute of Canada Clinical Trials Group.(58) This trial was designed to compare the complications and functional outcomes of sarcoma pat”