Mining the plasma proteome for cancer biomarkers

By S. Hanash, Sharon J. Pitteri, V. Faça. Nature, 2008

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Electrochemical Immunosensors for Detection of Cancer Protein Biomarkers (2012, methodology): “LC-MS-based proteomics are gaining importance for biomarker discovery but are currently too expensive and technically complex for routine clinical diagnostics.(14,15) Alternatively, antibody-coated microarrays are being developed in 96- or 384-well plate format using colorimetric detection methods (”
Systems medicine: the future of medical genomics and healthcare (2009, background): “These complete proteomes will probably serve as a reference for the subsequent development of simpler targeted assays [63], which will be complemented by array-based global surveys using affinity-based protein-specific reagents [64-66], and in certain cases, by single-cell proteomics using”