A promising sensing platform toward dopamine using MnO2 nanowires/electro-reduced graphene oxide composites

By Quanguo He, Jun Liu, Xiaopeng Liu, Guangli Li, Dongchu Chen, P. Deng, Jing Liang. Electrochimica Acta, 2019

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Abstract A promising sensing platform for the ultrasensitive detection of dopamine (DA) has been constructed using MnO2 nanowires-electrochemically reduced graphene oxide modified glassy carbon electrode (MnO2 NWs-ErGO/GCE). The proposed MnO2 NWs-ErGO/GCEs had the large electrochemical active area and relative low charge transfer resistant (Rct). As a result, the response peak current of the MnO2 NWs-ErGO is about 13 times higher than that of the bare GCE, demonstrating the remarkable electrocatalytic activity toward DA. The electrochemical kinetics revealed that DA oxidation is quasi-reversible reaction coupling with one electron and two protons. Three linear ranges (0.01 μM − 0.10 μM, 0.10 μM − 1.0 μM, and 1.0 μM − 80 μM) were obtained on the MnO2 NWs-ErGO/GCE, with a low detection limit of 1.0 nM (S/N = 3). Moreover, the response current was almost unaltered even in the presence of 100-fold ascorbic acid (AA) and uric acid (UA), suggesting MnO2 NWs-ErGO has good selectivity toward DA. Finally, the MnO2 NWs-ErGO/GCEs were successfully applied to detect DA in the injection solutions and human blood serum samples with high accuracy and good recovery.

View Paper: https://www.semanticscholar.org/paper/20d5fd2e3364dcbad88ddafa0e07108e1629f286