Lipid Droplets Finally Get a Little R-E-S-P-E-C-T

By Robert V Farese, T. Walther. Cell, 2009

979 citations recorded by the source corpus.

Long under appreciated as important cellular organelles, lipid droplets are finally being recognized as dynamic structures with a complex and interesting biology. In light of this newfound respect, we discuss emerging views on lipid droplet biology and speculate on the major advances to come.

Subfields: Biochemistry, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/20d53e021515ba162f0c3c638352008ace5cbca6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. Carla C. C. R. de Carvalho
2. A. Schulze
3. Maria-José Caramujo

In Molecular Biology

1. Adrian L. Harris
2. Carla C. C. R. de Carvalho
3. A. Schulze
4. Maria-José Caramujo
5. J. Joyce
6. J. Massagué
7. K. Pietras
8. A. Ostman

In Physiology

1. Carla C. C. R. de Carvalho
2. Maria-José Caramujo

Citations in the corpus

• The Various Roles of Fatty Acids (2018, background): “These triacylglycerols and sterol esters are then surrounded by a phospholipid monolayer and specific proteins thus forming lipid droplets, which are ubiquitously present in eukaryotic and prokaryotic cells (see [171,172].”
• Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness (2014, background): “CE accumulation is known to be a hallmark of atherosclerosis and hormone-producing organ (Farese and Walther, 2009; Murphy, 2001); however, its exact role in cancer progression remains elusive.”
• Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation. (2014, background): “Several proteins located at the surface of LDs (HIG2, Perilipin, ADRP, and Tip47) are essential for their membrane integrity (Bozza and Viola, 2010; Farese and Walther, 2009).”
• The Oil Bodies of Liverworts: Unique and Important Organelles in Land Plants (2013, background): “Lipid droplets consist of a hydrophobic core of stored fat, mostly neutral lipids such as triacylglycerols but also sterols and sterol esters, which are surrounded by a protein-bearing phospholipid hemimembrane (Farese and Walther, 2009; Beller et al., 2010; Digel et al., 2010).”