Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial.

By L. Bouadma, C. Luyt, F. Tubach, C. Cracco, A. Alvarez, C. Schwebel, F. Schortgen, S. Lasocki, B. Veber, M. Dehoux and 6 more. The Lancet, 2010

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Finding the "missing 50%" of invasive candidiasis: how nonculture diagnostics will improve understanding of disease spectrum and transform patient care. (2013, methodology): “used to reduce antibiotic consumption without adversely impacting outcomes [36].”
Implementing an Antibiotic Stewardship Program: Guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. (2016, background): “In a European multicenter study, Bouadma et al [172] examined de-escalation of therapy in 621 septic patients and demonstrated 2.7 more antibioticfree days in the PCT group (P .001), although days of antibiotic exposure per 1000 inpatient-days were high for each group (653 PCT vs 812 control) [172”
Guidelines for the management of adult lower respiratory tract infections - Full version (2011, neutral): “It has been shown that such rules work even in most severe cases, including pneumonia with septic shock, and even if clinicians are allowed to overrule the predefined stopping rule [420,421].”