Crystallographic analysis reveals common modes of binding of medium and long-chain fatty acids to human serum albumin.
By A. A. Bhattacharya, T. Grüne, S. Curry. Journal of Molecular Biology, 2000
868 citations recorded by the source corpus.
Subfields: Molecular Biology, Spectroscopy
View Paper: https://www.semanticscholar.org/paper/206d613b6d393c16a97166f5f7b585c18973a0ab
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
Citations in the corpus
- The Discovery and Development of Liraglutide and Semaglutide (2019, background): “The first human-based GLP-1RA to be evaluated in clinical trials for OW dosing was taspoglutide (BIM-51077, Aib8,35 GLP-1 [7-36] amide, Roche).”
- Binding of perfluorinated fatty acids to serum proteins (2003, background): “The topography and binding characteristics of all the fatty acid binding sites have been examined [30].”
- Structures of bovine, equine and leporine serum albumin. (2012, background): “…of binding sites, such as seven sites for long and medium fatty acids (FAs; Ashbrook et al., 1972, 1975), four additional sites for short FAs (Bhattacharya et al., 2000), two main sites for drugs (Sudlow et al., 1975, 1976), one site for bilirubin (Zunszain et al., 2008), which also binds…”
- Structural basis of the drug-binding specificity of human serum albumin. (2005, methodology): “The results are applicable to more physiologically relevant fatty acids, such as palmitate or oleate, since these exert the same conformational effects on the protein.(4,5) Although drug site 1 is co-incident with a fatty acid binding site (FA7),(4) this is likely to be a low-affinity site and in ea”
- The extraordinary ligand binding properties of human serum albumin (2005, background): “Differences in the orientation of domain I relative to domain II have been observed in crystal structures of HSA:myristate complexes prepared at different myristate to HSA mole ratios, and have been ascribed to different occupancy of FA2 site ( 22, 25 – 27, 29, 37 ).”