The ins and outs of MHC class II-mediated antigen processing and presentation
By P. Roche, K. Furuta. Nature reviews. Immunology, 2015
1,036 citations recorded by the source corpus.
Antigenic peptide-loaded MHC class II molecules (peptide–MHC class II) are constitutively expressed on the surface of professional antigen-presenting cells (APCs), including dendritic cells, B cells, macrophages and thymic epithelial cells, and are presented to antigen-specific CD4+ T cells. The mechanisms of antigen uptake, the nature of the antigen processing compartments and the lifetime of cell surface peptide–MHC class II complexes can vary depending on the type of APC. It is likely that these differences are important for the function of each distinct APC subset in the generation of effective adaptive immune responses. In this Review, we describe our current knowledge of the mechanisms of uptake and processing of antigens, the intracellular formation of peptide–MHC class II complexes, the intracellular trafficking of peptide–MHC class II complexes to the APC plasma membrane and their ultimate degradation.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/2050cd2cecd2ed2a43342c1ec0dcf7447d3058f1
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Citations in the corpus
- An introduction to deep learning on biological sequence data: examples and solutions (2017, background): “A peptide can only be recognized by a T cell, i.e. be a T cell epitope, if it is able to bind an MHCII molecule expressed by the host (Roche and Furuta, 2015).”
- Extracellular Vesicles: Unique Intercellular Delivery Vehicles. (2017, background): “Intracellular vesicle transport is crucial for MHC class-II mediated antigen presentation [70].”
- Vaccine adjuvants: mechanisms and platforms (2023, background): “The antigen presentation process involves the recognition, uptake, and internalization of antigens by APCs, followed by loading and presentation on the surface of APCs by the MHC.(54) The delivery systems can increase the antigen signals to be presented on the surface of APCs in one or more ways.”