Improving diffusion MRI using simultaneous multi-slice echo planar imaging
By Kawin Setsompop, Julien Cohen-Adad, Borjan A. Gagoski, T. Raij, Anastasia Yendiki, Boris Keil, Van J. Wedeen, Lawrence L. Wald. NeuroImage, 2012
376 citations recorded by the source corpus.
In diffusion MRI, simultaneous multi-slice single-shot EPI acquisitions have the potential to increase the number of diffusion directions obtained per unit time, allowing more diffusion encoding in high angular resolution diffusion imaging (HARDI) acquisitions. Nonetheless, unaliasing simultaneously acquired, closely spaced slices with parallel imaging methods can be difficult, leading to high g-factor penalties (i.e., lower SNR). The CAIPIRINHA technique was developed to reduce the g-factor in simultaneous multi-slice acquisitions by introducing inter-slice image shifts and thus increase the distance between aliased voxels. Because the CAIPIRINHA technique achieved this by controlling the phase of the RF excitations for each line of k-space, it is not directly applicable to single-shot EPI employed in conventional diffusion imaging. We adopt a recent gradient encoding method, which we termed “blipped-CAIPI”, to create the image shifts needed to apply CAIPIRINHA to EPI. Here, we use pseudo-multiple replica SNR and bootstrapping metrics to assess the performance of the blipped-CAIPI method in 3× simultaneous multi-slice diffusion studies. Further, we introduce a novel image reconstruction method to reduce detrimental ghosting artifacts in these acquisitions. We show that data acquisition times for Q-ball and diffusion spectrum imaging (DSI) can be reduced 3-fold with a minor loss in SNR and with similar diffusion results compared to conventional acquisitions.
Subfields: Orthopedics and Sports Medicine, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/1fea8d777c1d90b48e10dc34984831dc422d4a0c
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Orthopedics and Sports Medicine
In Radiology, Nuclear Medicine and Imaging
- David A. Feinberg
- Benedikt A. Poser
- David G. Norris
- Markus Barth
- Peter J. Koopmans
- Felix Breuer
- Kawin Setsompop
- Joseph V. Hajnal
Citations in the corpus
- Ultra-Fast MRI of the Human Brain with Simultaneous Multi-Slice Imaging (2013, methodology): “As above, higher spatial resolution was a strong driving force in the first applications of SMS-EPI to fMRI at [24] and to reduce the long acquisition time of diffusion imaging [11,12].”
- Simultaneous multislice (SMS) imaging techniques (2015, methodology): “This was solved by Setsompop et al (18), with a subtle but crucial modification that uses blipped rewinder gradients to keep the phase accumulation within the [-p, p] range, while imparting the same phase difference between adjacent k-space lines.”
- Complex diffusion-weighted image estimation via matrix recovery under general noise models (2018, positive): “In addition, accelerated encodings have been proposed for denser diffusion sampling, which generally reduce the SNR per volume but increase the SNR per unit time (Setsompop et al., 2012).”