The human protein atlas: A spatial map of the human proteome
By Peter J. Thul, C. Lindskog. Protein Science, 2018
1,079 citations recorded by the source corpus.
The correct spatial distribution of proteins is vital for their function and often mis‐localization or ectopic expression leads to diseases. For more than a decade, the Human Protein Atlas (HPA) has constituted a valuable tool for researchers studying protein localization and expression in human tissues and cells. The centerpiece of the HPA is its unique antibody collection for mapping the entire human proteome by immunohistochemistry and immunocytochemistry. By these approaches, more than 10 million images showing protein expression patterns at a single‐cell level were generated and are publicly available at www.proteinatlas.org. The antibody‐based approach is combined with transcriptomics data for an overview of global expression profiles. The present article comprehensively describes the HPA database functions and how users can utilize it for their own research as well as discusses the future path of spatial proteomics.
Subfields: Genetics, Molecular Biology, Spectroscopy
View Paper: https://www.semanticscholar.org/paper/1fabb2236262313fd8508bdc0c76edd592dcb018
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In Genetics
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Citations in the corpus
- A human cell atlas of fetal gene expression (2020, methodology): “For annotating cell type– specific gene features, we intersected the cell type–specific genes identified above with the predicted secreted andmembrane protein coding gene sets from the Human Protein Atlas (189), as well as the TF set annotated in the “motifAnnotations_hgnc” data from package RcisTar”