Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy.

By Michael F. O'Rourke, M. Safar. HYPERTENSION, 2005

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Mechanical factors in arterial aging: a clinical perspective. (2007, background): “A full iscussion is not possible here, but links between large artery tiffening and microvascular disease in brain and kidney, and amage to and dysfunction of these organs (42,51–53), are onsistent with the strong and causative association that had een described (41,42) on the basis of pathophysiolo”
Expert consensus document on arterial stiffness: methodological issues and clinical applications. (2006, background): “Another explanation is given by the differential input impedance in the brain compared with other systemic vascular beds.(108) Torrential flow and low resistance to flow in these organs expose small arterial vessels to the high-pressure fluctuations that exist in the carotid and vertebral arteries, ”