Asymmetric catalysis with bifunctional cinchona alkaloid-based urea and thiourea organocatalysts.

By S. Connon. Chemical Communications, 2008

697 citations recorded by the source corpus.

Cinchona alkaloid derivatives modified to include a (thio)urea component have emerged in the last three years as readily accessible, robust and tunable bifunctional organocatalysts for a range of synthetically useful transformations. The origins of these catalysts and the major developments in their application in enantioselective synthesis are reviewed.

Subfields: Molecular Biology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/1f8d85261231f6a6826b91189d2e3cdb8a002088