Fever and the thermal regulation of immunity: the immune system feels the heat
By S. Evans, E. Repasky, D. Fisher. Nature reviews. Immunology, 2015
1,063 citations recorded by the source corpus.
Fever is a cardinal response to infection that has been conserved in warm-blooded and cold-blooded vertebrates for more than 600 million years of evolution. The fever response is executed by integrated physiological and neuronal circuitry and confers a survival benefit during infection. In this Review, we discuss our current understanding of how the inflammatory cues delivered by the thermal element of fever stimulate innate and adaptive immune responses. We further highlight the unexpected multiplicity of roles of the pyrogenic cytokine interleukin-6 (IL-6), both during fever induction and during the mobilization of lymphocytes to the lymphoid organs that are the staging ground for immune defence. We also discuss the emerging evidence suggesting that the adrenergic signalling pathways associated with thermogenesis shape immune cell function.
Subfields: Critical Care and Intensive Care Medicine, Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/1f6af26441b91283fa996849daba93b073c3d200
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In Molecular Biology
Citations in the corpus
- Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis (2018, background): “In particular, the pyrogenic cytokine IL-6 (47) is present at higher abundance in the lungs and sera of C57BL/6J mice than in those of C3–/– mice.”