Heparin-protein interactions.

By I. Capila, Robert J. Linhardt. Angewandte Chemie, 2002

1,607 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

The Structure of Glycosaminoglycans and their Interactions with Proteins (2008, background): “At physiological pH, all carboxylic acid and sulphate groups are deprotonated, giving GAGs very high negative charge densities (heparin has the highest negative charge density of any known biomolecule) (7).”
Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events (2008, neutral): “dtd" [ ]> Heparin, a complex glycosaminoglycan polysaccharide, is widely used as an anticoagulant in a number of settings, including kidney dialysis and acute coronary syndrome”
Synthesis and medical applications of oligosaccharides (2007, background): “Heparin activates the serine protease inhibitor antithrombin III, which blocks thrombin and factor Xa in the coagulation cascad”
Control of matrix metalloproteinase catalytic activity. (2007, background): “…that is a more sulfated than HS, affects the activity of several coagulation cascade proteinases, such as antithrombin III, thrombin, and factor Xa (Capila and Linhardt, 2002; Conrad, 1998), as well as tryptase, chymase, and cathepsin B (Almeida et al., 2001; Alter et al., 1987; Hallgren et al.,…”