Effects of Early Nutritional Interventions on the Development of Atopic Disease in Infants and Children: The Role of Maternal Dietary Restriction, Breastfeeding, Timing of Introduction of…

By F. Greer, S. Sicherer, A. Burks. Pediatrics, 2008

1,069 citations recorded by the source corpus.

This clinical report reviews the nutritional options during pregnancy, lactation, and the first year of life that may affect the development of atopic disease (atopic dermatitis, asthma, food allergy) in early life. It replaces an earlier policy statement from the American Academy of Pediatrics that addressed the use of hypoallergenic infant formulas and included provisional recommendations for dietary management for the prevention of atopic disease. The documented benefits of nutritional intervention that may prevent or delay the onset of atopic disease are largely limited to infants at high risk of developing allergy (ie, infants with at least 1 first-degree relative [parent or sibling] with allergic disease). Current evidence does not support a major role for maternal dietary restrictions during pregnancy or lactation. There is evidence that breastfeeding for at least 4 months, compared with feeding formula made with intact cow milk protein, prevents or delays the occurrence of atopic dermatitis, cow milk allergy, and wheezing in early childhood. In studies of infants at high risk of atopy and who are not exclusively breastfed for 4 to 6 months, there is modest evidence that the onset of atopic disease may be delayed or prevented by the use of hydrolyzed formulas compared with formula made with intact cow milk protein, particularly for atopic dermatitis. Comparative studies of the various hydrolyzed formulas also indicate that not all formulas have the same protective benefit. There is also little evidence that delaying the timing of the introduction of complementary foods beyond 4 to 6 months of age prevents the occurrence of atopic disease. At present, there are insufficient data to document a protective effect of any dietary intervention beyond 4 to 6 months of age for the development of atopic disease.

Subfields: Immunology and Allergy, Pharmacy, Physiology

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How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology and Allergy

1. S. Sicherer
2. K. Beyer
3. Hugh A. Sampson

In Pharmacy

1. Veronica Graham
2. S. Sicherer
3. Hugh A. Sampson

In Physiology

1. S. Sicherer
2. K. Beyer
3. Veronica Graham

Citations in the corpus

• Breastfeeding and the Use of Human Milk (2005, neutral): “13,26 There are con fl icting studies that examine the timing of adding complementary foods after 4 months and the risk of allergy, including food allergies, atopic dermatitis, and asthma, in either the allergy-prone or nonatopic individual.”
• ICON: food allergy. (2012, background): “The American Academy of Pediatrics and the NIAID-sponsored guidelines, as well as the Australasian Society of Clinical Immunology and Allergy Guidelines, do not recommend restrictions on consuming potential food allergens during pregnancy or lactation.(2,88,89) These recommendations are similar to t”
• Australian Dietary Guidelines (2006, background): “Only women who are allergic to these foods themselves need to avoid them [362, 369-372].”