Saponins as cytotoxic agents: a review

By I. Podolak, A. Galanty, D. Sobolewska. Phytochemistry Reviews, 2010

696 citations recorded by the source corpus.

Saponins are natural glycosides which possess a wide range of pharmacological properties including cytotoxic activity. In this review, the recent studies (2005–2009) concerning the cytotoxic activity of saponins have been summarized. The correlations between the structure and the cytotoxicity of both steroid and triterpenoid saponins have been described as well as the most common mechanisms of action.

Subfields: Biomaterials, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1efdc6707e4b7293a550a7a42df11c53c5a2da3e

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In Molecular Biology

1. A. Osbourn
2. S. Walia

Citations in the corpus

• Phytochemical biopesticides: some recent developments (2017, background): “Due to the amphiphilic nature, such saponins produce foam and exhibit cell lysis activity leading to pore formation and cell membrane permeation (Sparg et al. 2004, Vincken et al. 2007, Podolak et al. 2010).”
• Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications (2020, neutral): “132,134 In summary, the above methods do not allow the combination of therapeutic agents with different properties to be loaded simultaneously, whether the pre-secretory loading or the post-secretory loading.”
• Triterpene biosynthesis in plants. (2014, background): “C-21 acylation is a common feature of many of the most cytotoxic triterpene glycosides (105).”