Dengue and dengue hemorrhagic fever.

By D. Gubler, Eng Eong Ooi, S. Vasudevan, J. Farrar. 2014

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The global distribution and burden of dengue (2013, neutral): “The Americas contributed 14% (13 [9-18] million infections) of apparent infections worldwide, of which over half occurred in Brazil and Mexico.”
Epidemiology of dengue: past, present and future prospects (2013, background): “The disease was referred to as ‘water poison’ and was associated with flying insects.(26) Epidemics that resembled dengue, with similar disease course and spread, occurred as early as 1635 and 1699 in the West Indies and Central America, respectively.”
Dengue and severe dengue (2025, positive): “…instance, after the successful Pan American Aedes eradication program was halted in the 1960s, Aedes aegypti was reintroduced into the Americas as early as the 1970s; ensuing increase in trans-continental travel introduced DENVs back into cities of Latin America, causing repeated outbreaks (184).”
Exploring dengue genome to construct a multi-epitope based subunit vaccine by utilizing immunoinformatics approach to battle against dengue infection (2017, background): “plasma leaking, fluid accumulation, difficulty in breathing, clammy skin, blood in vomit, drowsiness and black, tarry stool are associated with the severe dengue fever also called as dengue hemorrhagic fever (DHF) 1, 5 .”