Epileptic Seizures May Begin Clinical Study Hours in Advance of Clinical Onset: A Report of Five Patients

By Brian Litt, R. Esteller, J. Echauz, M. D'Alessandro, R. Shor, Thomas R. Henry, P. Pennell, C. Epstein, R. Bakay, M. Dichter and 1 more. 2001

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Seizure detection, seizure prediction, and closed-loop warning systems in epilepsy. (2014, background): “The evaluation of EEGs from a series of patients with mesial temporal lobe epilepsy, for example, suggests that EEG changes can be noted as early as 7 h prior to seizure onset [91].”
Seizure prediction: the long and winding road. (2007, methodology): “Similarly, the promising performance of the accumulated energy (Litt et al., 2001) could not be reproduced in later studies (Maiwald et al.”
Nonlinear dynamical analysis of EEG and MEG: review of an emerging field. (2005, background): “…and phase clustering for the assessment of changes in the local dynamics (Iasemidis et al., 2001, 2004; Kalitzin et al., 2002; Li et al., 2003; Litt et al., 2001; Moser et al., 1999; Osorio et al., 2001; Schindler et al., 2001; Schindler et al., 2002; Van Drongelen et al., 2003; Van Putten,…”
Adaptive epileptic seizure prediction system (2003, result): “transition to date [22]–[27] represent retrospective analyses, that is, after the occurrence of a seizure, they work backward in time and try to identify the changes of the estimated measures from the EEG in the vicinity of the seizure, as compared with the ones”