AMPK and SIRT1: a long-standing partnership?

By N. Ruderman, X. J. Xu, Lauren Nelson, José M. Cacicedo, A. Saha, Fan Lan, Y. Ido. American Journal of Physiology. Endocrinology and Metabolism, 2010

918 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/1e802db129429c705a933a4d5c0b3518b24caab8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Geriatrics and Gerontology

1. Ping Gao
2. Antero Salminen
3. Huafeng Zhang
4. Linchong Sun
5. K. Kaarniranta

In Molecular Biology

1. Ping Gao
2. David Carling
3. José M. Cacicedo
4. N. Ruderman
5. M. Prentki
6. Huafeng Zhang
7. Linchong Sun
8. D. Hardie

In Physiology

1. Ping Gao
2. David Carling
3. Antero Salminen
4. Huafeng Zhang
5. Linchong Sun
6. K. Kaarniranta

Citations in the corpus

• AMPK, insulin resistance, and the metabolic syndrome. (2013, positive): “In model systems, sustained decreases in AMPK activity accompany IR, whereas AMPK activation increases insulin sensitivity (5, 6, 13).”
• Autophagy and the integrated stress response (2010, neutral): “b (CaMKKß, which is activated by cytosolic Ca), and TGFßactivated kinase-1 (TAK-1, which is also involved in IKK activation), can activate AMPK by phosphorylating a threonine residue on its catalytic a subunit (Ruderman et al., 2010).”
• Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “, 2000), AMP-activated protein kinase (AMPK) (Ruderman et al., 2010; Gongol et al., 2018; Yuan et al., 2020), and mechanistic target of rapamycin kinase (mTOR) (Laribee, 2018; Zeng et al.”
• AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan (2011, background): “AMPK and SIRT1 are evolutionary conserved partners which have similar functions in metabolism and cellular survival [49].”